BDBM418315 (2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin-4-yl}-5-oxo- 5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl)- N-[(1S)-1-(3-fluoro-5-methoxyphenyl)- 2-hydroxyethyl]propanamide::US10457669, Example 1126::US11001575, Example 1126

SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ncc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl

InChI Key InChIKey=MMRFBAAYXFQBMP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 418315   

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418315((2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 2.80nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418315((2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 2.80nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMitogen-activated protein kinase 1(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM418315((2R)-2-(3-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed