BDBM429304 CVD-0006354::acs.jmedchem.1c00409_ST.426::indole chloropyridinyl-ester derived, 1::jm5b01461, Compound 124

SMILES Clc1cncc(OC(=O)c2cccc3[nH]ccc23)c1

InChI Key InChIKey=BOSZJNSICHFHMA-UHFFFAOYSA-N

Data  14 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429304   

TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataIC50: 30nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataIC50: 30nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataIC50: 250nMAssay Description:Inhibition of SARS CoV-2 MProMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataIC50: 313nMAssay Description:Inhibition of full-length SARS CoV-2 MPro expressed in Escherichia coli BL21(DE3) using Boc-Abu-Tle-Leu-Gln-AMC as substrate incubated for 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataEC50:  6.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandChemical structure of BindingDB Monomer ID 429304BDBM429304(jm5b01461, Compound 124 | indole chloropyridinyl-e...)
Affinity DataEC50:  6.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed