BDBM448319 GC-376::GC376::US20250188102, Compound GC-376

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC1CCNC1=O)C(O)S([O-])(=O)=O

InChI Key InChIKey=BSPZFJDYQHDZNR-UHFFFAOYSA-M

Data  1 KI  38 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 448319   

TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His-tagged SAR-CoV-2 Main protease expressed in Escherichia coli BL21/DE3 using Edans-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant SARS-CoV-2 Native Main protease expressed in Escherichia coli using MCA-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant His-tagged SAR-CoV-2 Main protease expressed in Escherichia coli BL21/DE3 using MCA-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant SARS-CoV-2 Native Main protease expressed in Escherichia coli using using Edans-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed