BDBM448319 GC-376::GC376::US20250188102, Compound GC-376

SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC1CCNC1=O)C(O)S([O-])(=O)=O

InChI Key InChIKey=BSPZFJDYQHDZNR-UHFFFAOYSA-M

Data  1 KI  38 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 448319   

TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His-tagged SAR-CoV-2 Main protease expressed in Escherichia coli BL21/DE3 using Edans-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 37nMAssay Description:The enzymatic inhibition assay was carried out with a final concentration of 100 nM recombinant SARS-CoV-2 Mpro and 20 μM FRET substrate. For th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCaspase-3(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 2.00E+4nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 2.00E+4nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 33nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetProcathepsin L(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 0.990nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 74nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin K(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 0.560nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 880nMAssay Description:Inhibition of SARS CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant SARS-CoV-2 Native Main protease expressed in Escherichia coli using MCA-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant His-tagged SAR-CoV-2 Main protease expressed in Escherichia coli BL21/DE3 using MCA-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant SARS-CoV-2 Native Main protease expressed in Escherichia coli using using Edans-labeled substrate by FRET-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetCathepsin K(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 0.260nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 190nMAssay Description:Inhibition of SARS-CoV-2 3CL protease measured after 10 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(MERS-CoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 274nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-229E)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-OC43)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-HKU1)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(HCoV-NL63)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 107nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2025
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(HCoV-HKU1)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 12nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 190nMAssay Description:Pure SARS-CoV-2 3CLP was obtained as previously described in detail, and the enzymatic activity was confirmed according to an established protocol; s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 34nMAssay Description:SARS-CoV-2 3CLpro expression and purification is based on a published procedure and our modified protocol is found in the supplementary file. A highl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 30nMAssay Description:The assays are from references cited in this article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 31nMAssay Description:The assays are from references cited in this article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 44nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 44nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 28nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 28nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 69nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Jkt Biopharma Co.

US Patent
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 120nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 4.40nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 43nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
The University of Arizona

LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataIC50: 74nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM448319(GC376 | GC-376 | US20250188102, Compound GC-376)
Affinity DataKi:  4.40E+3nM IC50: 4.40E+4nMAssay Description:Please point to the patents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article
PubMed