BDBM449730 US10703733, Example 343::US10988451, Example 343::US11643400, Example 343::US11667652, Example 34

SMILES C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1

InChI Key InChIKey=RQSNJVWEFDNXDS-DPHNLKLESA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 449730   

LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50:  0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50:  0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50:  0.0880nMAssay Description:Inhibition of the MCL1 and Bim interaction was measured in the following AlphaLISA assay.Recombinant human MCL1 protein (C-terminal 6×His Tagged MCL1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM449730(US10703733, Example 343 | US10988451, Example 343 ...)
Affinity DataIC50:  0.0190nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent