BDBM449736 US10703733, Example 349::US10988451, Example 349::US11643400, Example 349

SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=CDUPCFKIBQIWFA-MISPZJIBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 449736   

LigandPNGBDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50:  0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50:  0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM449736(US10703733, Example 349 | US10988451, Example 349 ...)
Affinity DataIC50:  0.0260nMAssay Description:The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent