BDBM50000655 (4R,7S,10R)-10-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3-dimethyl-6,9-dioxo-1,2-dithia-5,8-diaza-cycloundecane-4-carboxylic acid::10-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7-benzyl-3,3-dimethyl-6,9-dioxo-1,2-dithia-5,8-diaza-cycloundecane-4-carboxylic acid::CHEMBL39192

SMILES CC1(C)SSC[C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]1C(O)=O

InChI Key InChIKey=BLNPATOSLCUUSL-UHFFFAOYSA-N

Data  13 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50000655   

TargetDelta-type opioid receptor(Mouse)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataIC50: 4.20nMAssay Description:Inhibitory concentration against delta opioid receptor in mouse vas deferens assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataIC50: 460nMAssay Description:Inhibitory concentration of compound against mu opioid receptor in guinea pig ileum assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  0.740nMAssay Description:Binding affinity against Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  0.740nMAssay Description:Binding affinity against Opioid receptor delta 1 in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  0.740nMAssay Description:Compound was evaluated for binding affinity against delta opioid receptor of mouse vas deferens using [3H]-DPDPEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against Opioid receptor delta 1 in guinea pig brain homogenates, using [3H]DPDPE as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  1.80nMAssay Description:Compound was tested for the inhibition of [3H]- [D-Pen2, D-Pen5]-enkephalin (DPDPE) binding to Opioid receptor delta 1 in guinea pig brain homogenate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  52nMAssay Description:Binding affinity against mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  52nMAssay Description:Binding affinity against mu opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor of guinea pig brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  107nMAssay Description:Binding affinity against opioid receptor mu in guinea pig brain homogenates, using [3H]DAMGO as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi:  107nMAssay Description:Compound was tested for the inhibition of [3H]- [D-Ala2, N-MePhe4, Gly5-ol]-enkephalin (DAMGO) binding to Opioid receptor mu 1 in guinea pig brain ho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against Opioid receptor kappa 1 in guinea pig brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against opioid receptor kappa from guinea pig brain homogenates, using [3H]U-69593 as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50000655(CHEMBL39192 | 10-[2-Amino-3-(4-hydroxy-phenyl)-pro...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for the inhibition of [3H]- (U69,593) binding to Opioid receptor kappa 1 in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed