BDBM50020874 (3-Chloro-phenyl)-(4-phenyl-phthalazin-1-yl)-amine::CHEMBL332898

SMILES Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1

InChI Key InChIKey=CEHQLKSLMFIHBF-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50020874   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50020874(CHEMBL332898 | (3-Chloro-phenyl)-(4-phenyl-phthala...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PDE5 (unknown origin) using 0.4 uM cGMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50020874(CHEMBL332898 | (3-Chloro-phenyl)-(4-phenyl-phthala...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50020874(CHEMBL332898 | (3-Chloro-phenyl)-(4-phenyl-phthala...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human platelets PDE2 at 10 uM using cAMP as substrate incubated for 30 mins in presence of [3H]cAMP and cGMP by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed