BDBM50022741 (5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid::CHEMBL66389

SMILES CC1C(CCc2ccc(cc2)C(=O)NC(CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12

InChI Key InChIKey=CJYJOFHMOJCKDH-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50022741   

TargetThymidylate synthase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluated for inhibition of thymidylate synthase (TS) from Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 1.00E+5nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) from Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compound was tested for inhibition of AICAR formyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of GAR transformylase from mammalian L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of GAR transformylase from mammalian MancaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataIC50: 720nMAssay Description:Inhibition of GAR transformylase from Lactobacillus caseiMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mouse)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50022741((5RS, 6RS) 2-{4-[2-(2-Amino-5-methyl-4-oxo-3,4,5,6...)
Affinity DataKi: >1nMAssay Description:Evaluated for inhibition of dihydrofolate reductase (DHFR) isolated from L1210 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed