BDBM50033408 CHEMBL3357656

SMILES [H][C@]12CCCO[C@]1([H])[C@@]1(N=C(N)N(C)C1=O)c1cc(ccc1O2)-c1cccnc1F

InChI Key InChIKey=GZRDWAATBYKNGI-FTRWYGJKSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50033408   

TargetBeta-secretase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033408(CHEMBL3357656)
Affinity DataIC50:  48nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033408(CHEMBL3357656)
Affinity DataIC50:  12nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50033408(CHEMBL3357656)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of cathepsin D purified from human spleen after 1 hr by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed