BDBM50067678 (6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione::(6alpha)-6-methyl-3,20-dioxopregn-4-en-17-yl acetate::17-Acetoxy-6alpha-methylprogesterone::17alpha-Hydroxy-6alpha-methylprogesterone acetate::6-alpha-Methyl-17-alpha-acetoxyprogesterone::6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate::6alpha-Methyl-17-acetoxy progesterone::6alpha-Methyl-17alpha-hydroxyprogesterone acetate::6alpha-Methyl-4-pregnene-3,20-dion-17alpha-ol acetate::MEDROXYPROGESTERONE::Medroxyacetate progesterone::Medroxyprogesterone 17-acetate::Methylacetoxyprogesterone::Metigestrona::US9271961, MPA::medroxyprogesterone acetate
SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
InChI Key InChIKey=PSGAAPLEWMOORI-PEINSRQWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 69 hits for monomerid = 50067678
Affinity DataKi: 0.339nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:The binding affinity of the compound was determined on Human progesterone receptor (hPR-A) using progesterone as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:Binding affinity against human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells.More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity at human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity against human androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity against baculovirus expressed human androgen receptor (hAR)More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of DHT from human androgen receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity was determined on Human androgen receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity against human glucocorticoid receptor expressed in SF-12 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of Dexamethasone from human glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 13.2nMAssay Description:Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 280nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 1.60E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 700nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of [3H]P4 to progesterone receptor (PR) of human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Effective concentration of progesterone receptor agonist induction of alkaline phosphatase activity in human T47D breast carcinoma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Effective concentration (EC50) against human progesterone receptor expressed in CV-1 cellMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibitory activity (IC50) against human androgen receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity to the human progesterone receptor(hPR)assayed in CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory activity (IC50) against human glucocorticoid receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity (IC50) against human mineralocorticoid receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Effective concentration against glucocorticoid receptor in human lung A549 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Effective concnetration against Androgen receptor in mouse fibroblast L929 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity against human progesterone receptor expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against human Mineralocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inihibition of human androgen receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at human progesterone receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human progesterone receptor in human T47D cells assessed as alkaline phosphatase activityMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant AKR1C3 (unknown origin) assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of recombinant AKR1C2 (unknown origin) assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C1(Homo sapiens (Human))
University Of Pennsylvania
US Patent
University Of Pennsylvania
US Patent
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant AKR1C1 expressed in Escherichia coli assessed as decrease in oxidation of 1-acenaphthenol substrate by spectrophotome...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity against Human glucocorticoid receptor(hGR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonistic activity was determined in Human mineralocorticoid receptor(hMR) of CV-1 cells in cotransfection assay.More data for this Ligand-Target Pair
Affinity DataEC50: 6.10nMAssay Description:Agonistic activity against Human androgen receptor(hAR) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
Affinity DataEC50: 0.330nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair