BDBM50069447 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one::2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::CHEMBL623::NEFAZODONE::US9138393, Nefazodone HCl::US9144538, Nefazodone HCl
SMILES CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CCOc1ccccc1
InChI Key InChIKey=VRBKIVRKKCLPHA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 62 hits for monomerid = 50069447
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 360nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 360nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKd: 200nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Competitive inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 transepithelial transport (basal to apical) (R123: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 6.11E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 5.80nMAssay Description:Binding affinity to 5-HT2AMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity to rat 5HT2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Binding affinity to rat 5HT1A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 137nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Binding affinity to SERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent dopamine transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
TargetSodium-dependent serotonin transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 570nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL