BDBM50084978 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL40919::Kaempferide::Kaempferol 4'-methyl ether

SMILES COc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O

InChI Key InChIKey=SQFSKOYWJBQGKQ-UHFFFAOYSA-N

Data  12 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50084978   

TargetMitogen-activated protein kinase 14(Human)
Eberhard Karls University of Tuebingen

LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 3.29E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 10(Human)
Eberhard Karls University of Tuebingen

LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 5.25E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to nucleotide-binding domain (NBD2) of P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kyoto Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
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PubMed
TargetCytochrome P450 1A2(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 509nMAssay Description:Inhibition of human CYP1A2 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A1(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 88nMAssay Description:Inhibition of human CYP1A1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human CYP1B1 by EROD assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
DéPartement De Pharmacochimie MoléCulaire Umr-Cnrs 5063

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataKd:  4.50E+3nMAssay Description:Compound was tested for the binding affinity towards recombinant NBD2 C-terminal cytotoxic nucleotide-binding domain of mouse P-GlycoproteinMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A1(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP1A1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1B1(Human)
University of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CYP1B1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Chosun University

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataKd:  4.47E+3nMAssay Description:Binding affinity to ABCB1 nucleotide binding domain 2More data for this Ligand-Target Pair
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PubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 1.66E+6nMAssay Description:In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI)More data for this Ligand-Target Pair
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TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by spectrophotom...More data for this Ligand-Target Pair
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TargetHistone-lysine N-methyltransferase SETD7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50084978(Kaempferide | Kaempferol 4'-methyl ether | CHEMBL4...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SET7 overexpressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins followed by addition of SAM as substrate and bio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed