BDBM50103521 Actos::CHEBI:8228::Duetact::Pioglitazone::US20240091210, Compound Pioglitazone

SMILES CCc1ccc(nc1)CCOc2ccc(cc2)C[C@@H]3C(=O)NC(=O)S3

InChI Key InChIKey=HYAFETHFCAUJAY-UHFFFAOYSA-N

Data  11 KI  21 IC50  2 Kd  29 EC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50103521   

TargetCDGSH iron-sulfur domain-containing protein 1(Human)
West Virginia University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103521BDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed
TargetCDGSH iron-sulfur domain-containing protein 2(Human)
West Virginia University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103521BDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataIC50: 4.80E+3nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged NAF1 expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Human)
West Virginia University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50103521BDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataIC50: 8.65E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2018
Entry Details Article
PubMed