BDBM50103521 Actos::CHEBI:8228::Duetact::Pioglitazone::US20240091210, Compound Pioglitazone

SMILES CCc1ccc(nc1)CCOc2ccc(cc2)C[C@@H]3C(=O)NC(=O)S3

InChI Key InChIKey=HYAFETHFCAUJAY-UHFFFAOYSA-N

Data  11 KI  21 IC50  2 Kd  29 EC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50103521   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at PPARgamma in human BMMSC cells assessed as promotion of adiponectin secretion by measuring increase in adiponectin level in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataKi:  300nMAssay Description:Displacement of fluormone pan-PPARgreen from GST-tagged human PPARgamma ligand binding domain by LanthaScreen TR-FRET competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled PRIP/RAP250 coactivat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC1 coactivator pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataEC50:  3.50E+3nMAssay Description:Agonist activity at GST-tagged PPAR-gamma ligand binding domain (unknown origin) assessed as recruitment of fluorescein-labeled SRC3 coactivator pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)