BDBM50132003 (Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime::(Z)-1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime::1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-oxime::1H,1'H-[2,3']Biindolylidene-3,2'-dione 3-oxime::3-(3-(hydroxyimino)indolin-2-ylidene)indolin-2-one::CHEMBL126077

SMILES Oc1[nH]c2ccccc2c1-c1[nH]c2ccccc2c1N=O

InChI Key InChIKey=FQCPPVRJPILDIK-UHFFFAOYSA-N

Data  17 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50132003   

TargetAurora kinase A(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human recombinant aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 700nMAssay Description:Inhibition of against CDK2/cyclinE1 (unknown origin) using Ulight-CFFKNIVTPRTPPPSQGK-amide substrate and ATP incubated for 15 mins by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of against CDK9/cyclinT1 (unknown origin) using Ulight-CFFKNIVTPRTPPPSQGK-amide substrate and ATP incubated for 90 mins by fluorescence ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 100nMAssay Description:Inhibition of mammalian CDK5/p25More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Walter Reed Army Institute of Research

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Plasmodium falciparum cyclin-dependent kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetMO15-related protein kinase Pfmrk(malaria parasite P. falciparum)
Walter Reed Army Institute of Research

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, PfmrkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 100nMAssay Description:Inhibition of cyclin-dependent kinase 5/p25More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant aurora C kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 22nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Cdk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50132003((Z)-1H,1''H-[2,3'']Biindolylidene-3,2''-dione 3-ox...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Cdk5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed