BDBM50139762 CHEMBL349373::[(16R,20S)-18-((S)-Carbamoylmethyl)-14-(5-methyl-indol-1-ylmethyl)-20-(S)-oxo-8,17-dioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid::[(E)-(R)-18-Carbamoylmethyl-14-(5-methyl-indol-1-ylmethyl)-8,20-dioxo-17-(S)-oxo-10-((1S,4S)-4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid
SMILES Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C3)c3ccc(CP(O)(O)=O)cc3)ccc2c1
InChI Key InChIKey=WYANCIQWFFQARP-AZSCFGFUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50139762
Affinity DataKd: 0.0750nMAssay Description:Binding affinity to SH2 domain of GRB2More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SH2 domain of GRB2 in human MDA-MB-231 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of SH2 domain of GRB2 in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 1.47nMAssay Description:Dissociation constant value against growth factor receptor bound protein 2More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against growth factor receptor bound protein 2More data for this Ligand-Target Pair
Affinity DataKd: 0.0930nMAssay Description:In vitro binding affinity for Grb2 SH2 domainMore data for this Ligand-Target Pair