BDBM50152554 4-(2-Chloro-phenyl)-2,4-dioxo-butyric acid::CHEMBL363721::Sacchettini_3

SMILES OC(=O)C(=O)CC(=O)c1ccccc1Cl

InChI Key InChIKey=BLWCAZYQFBZYOK-UHFFFAOYSA-N

Data  3 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50152554   

TargetGlcB(Homo sapiens (Human))
D3R

LigandPNGBDBM50152554(4-(2-Chloro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1Cl
Show InChI InChI=1S/C10H7ClO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 500nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In DepthDetails PubMed
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys Inc

Curated by ChEMBL
LigandPNGBDBM50152554(4-(2-Chloro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1Cl
Show InChI InChI=1S/C10H7ClO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 3.81E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys Inc

Curated by ChEMBL
LigandPNGBDBM50152554(4-(2-Chloro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1Cl
Show InChI InChI=1S/C10H7ClO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 3.51E+3nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair