BDBM50152579 4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid::CHEMBL364328::Sacchettini_2

SMILES OC(=O)C(=O)CC(=O)c1ccccc1F

InChI Key InChIKey=XWLTWDLBAOMBJP-UHFFFAOYSA-N

Data  4 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50152579   

TargetGlcB(Homo sapiens (Human))
D3R

LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1F
Show InChI InChI=1S/C10H7FO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 240nMAssay Description:DNTB-Coupled_Enzyme_AssayMore data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In DepthDetails PubMed
TargetProtein-tyrosine phosphatase 1B(Homo sapiens (Human))
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1F
Show InChI InChI=1S/C10H7FO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
TargetDNA excision repair protein ERCC-5(Homo sapiens (Human))
Athersys Inc

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1F
Show InChI InChI=1S/C10H7FO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 7.85E+4nMAssay Description:Concentration required for 50% inhibition of Xeroderma pigmentosum GMore data for this Ligand-Target Pair
TargetFlap endonuclease 1(Homo sapiens (Human))
Athersys Inc

Curated by ChEMBL
LigandPNGBDBM50152579(4-(2-Fluoro-phenyl)-2,4-dioxo-butyric acid | CHEMB...)
Show SMILES OC(=O)C(=O)CC(=O)c1ccccc1F
Show InChI InChI=1S/C10H7FO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15)
Affinity DataIC50: 1.45E+4nMAssay Description:Concentration required for 50% inhibition of Flap endonuclease-1More data for this Ligand-Target Pair