BDBM50158100 CHEMBL1614812

SMILES CNCCN1CCC(CC1)c1ccc2[nH]c(c(F)c2c1)-c1ccccc1OC

InChI Key InChIKey=SPSRJAZORUFUOI-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50158100   

TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  30nMAssay Description:Inhibition of human PRMT4 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity as...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  30nMAssay Description:Inhibition of human full length GST-tagged PRMT4 assessed as inhibition of histone H3 methylation measured after 60 to 90 mins using [3H]-SAM by TopC...More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant full-length human GST-tagged PRMT4 expressed in Spodoptera frugiperda insect cells using histone H3 as substrate measured a...More data for this Ligand-Target Pair
TargetToll-like receptor 9(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  2.33E+4nMAssay Description:Antagonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as inhibition of ODN2006-induced NFkappaB and AP-1 activation preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  30nMAssay Description:Inhibition of full-length GST-tagged CARM1 (unknown origin) using histone H3 substrate and [3H]SAM by scintillation counting methodMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  610nMAssay Description:Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50158100(CHEMBL1614812)
Affinity DataIC50:  30nMAssay Description:Inhibition of full-length GST-tagged CARM1 (unknown origin) using histone H3 substrate and [3H]SAM by scintillation counting methodMore data for this Ligand-Target Pair