BDBM50180268 CHEMBL3814662

SMILES O=c1c(OCCN2CCn3c2nc2ccccc32)cn(CC2CC2)nc1-c1ccnn1-c1ccccc1

InChI Key InChIKey=PMQGNBOUOYQTPQ-UHFFFAOYSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50180268   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE11A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE9A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE8A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE6ABMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of human full length PDE10A2 expressed in African green monkey COS7 cells using [3H]cGMP as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE4D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE3AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE2A3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE1AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50180268(CHEMBL3814662)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human PDE5A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed