BDBM50210256 CHEMBL26300::Sulfamic acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-benzo[1,2-d;3,4-d']bis[1,3]dioxol-3a-ylmethyl ester::Topiramate, 3

SMILES CC1(C)O[C@@H]2CC[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1

InChI Key InChIKey=DIISHYBDWUTJIE-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50210256   

TargetCarbonic anhydrase 7(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  0.900nM ΔG°:  -12.1kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
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TargetCarbonic anhydrase 12(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  3.80nM ΔG°:  -11.3kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
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TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  10nM ΔG°:  -10.7kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 5B, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  30nM ΔG°:  -10.1kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 6(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  45nM ΔG°:  -9.85kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 13(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  47nM ΔG°:  -9.82kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  58nM ΔG°:  -9.70kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  63nM ΔG°:  -9.65kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  250nM ΔG°:  -8.85kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 14(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  1.46E+3nM ΔG°:  -7.82kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 4(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  4.90E+3nM ΔG°:  -7.12kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 3(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM50210256(CHEMBL26300 | Topiramate, 3 | Sulfamic acid (3aS,5...)
Affinity DataKi:  7.80E+5nM ΔG°:  -4.17kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed