BDBM50240725 (2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol::CHEMBL108084::Fagomine

SMILES OC[C@H]1NCC[C@@H](O)[C@@H]1O

InChI Key InChIKey=YZNNBIPIQWYLDM-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50240725   

TargetGlycogen debranching enzyme(Rabbit)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rabbit muscle amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetNon-lysosomal glucosylceramidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCeramide glucosyltransferase(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 8.20E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 1.40E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-L-fucosidase was determined in bovine epididymisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetNeutral alpha-glucosidase AB(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 1.00E+6nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-mannosidase (golgi II) was determined in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 1.50E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetNeutral alpha-glucosidase C(Mouse)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 4.60E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Bovine)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 5.20E+5nMAssay Description:Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Bovine)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 3.80E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of rat intestinal brush border membrane sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 4.60E+5nMAssay Description:Inhibition of rat intestinal brush border membrane isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 8.20E+5nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Bovine)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of bovine liver beta-galactosidase assessed as production of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of bovine liver beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50240725((2R,3R,4R)-2-Hydroxymethyl-piperidine-3,4-diol | F...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of Wistar rat intestinal isomaltase by glucose B-testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed