BDBM50246120 CHEMBL4082745
SMILES Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O
InChI Key InChIKey=FIKQZQDYGXAUHC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 19 hits for monomerid = 50246120
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1(Rattus norvegicus)
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Activation of rat hepatocytes AMPK alpha1/beta2/gamma1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Binding affinity to DP2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >8.60E+4nMAssay Description:Binding affinity to DP2 receptor (unknown origin) in presence of 10% human serumMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 1 alpha1/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-2(Homo sapiens)
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 21nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 2 alpha1/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-3(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 19nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 3 alpha1/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-2(Homo sapiens)
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 118nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 5 alpha1/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-3(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 2.86E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 6 alpha1/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 9 alpha2/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 10 alpha2/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-2/subunit gamma-2(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 23nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 11 alpha2/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-2/subunit gamma-1(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 40nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 4 alpha1/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-2(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 22nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 8 alpha2/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 35nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 12 alpha2/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXR transfected in human hepatoma cells assessed as induction of CYP3A4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PRAK expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Metabasis Therapeutics
Curated by ChEMBL
Metabasis Therapeutics
Curated by ChEMBL
Affinity DataEC50: 8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair