BDBM50252909 (3R,4R)-1-((9-Deazahypoxanthin-9-yl)methyl)-4-fluoro-4-hydroxymethyl pyrrolidin-3-ol::CHEMBL522870::Immucillins, 5
SMILES OC[C@]1(F)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@H]1O
InChI Key InChIKey=VFUSATHXTREUCA-PRHODGIISA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50252909
Affinity DataKi: 1.82nMAssay Description:Inhibition of human purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of human purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 260nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.07E+3nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 2 hits for monomerid = 50252909
ITC DataΔG°: -12.0kcal/mole logk: 6.24E+8
pH: 7.4 T: 25.00°C
pH: 7.4 T: 25.00°C
ITC DataΔH°: -15.6kcal/mole
pH: 7.4 T: 27.00°C
pH: 7.4 T: 27.00°C