BDBM50368125 ADENOSINE DIPHOSPHATE::ADP

SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Key InChIKey=XTWYTFMLZFPYCI-UHFFFAOYSA-N

Data  3 KI  4 IC50  6 Kd  16 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50368125   

TargetP2Y purinoceptor 11(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetKinesin-like protein KIFC1(Human)
Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  400nMAssay Description:Displacement of FP-Probe from N-terminal His-tagged full length recombinant human HSET incubated for 2 hrs by fluorescence polarization based competi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSensor protein kinase WalK(Staphylococcus aureus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataIC50: 7.19E+3nMAssay Description:Inhibition of Streptococcus pneumoniae VicK autophosphorylation using compound at non-aggregating concentration after 30 mins in presence of [gamma-3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  6.30E+4nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged non-autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  4.10E+3nMAssay Description:Binding affinity to recombinant human biotinylated N-terminal GST-tagged autophosphorylated TAK1 (1 to 303 residues) fused with TAB1 (437 to 504 resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2019
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibitory activity (IC50) against human phosphatidylinositol 4-kinase at the ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  100nMAssay Description:Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetP2Y purinoceptor 11(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetEndoplasmin(Dog)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataIC50: 1.14E+4nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataIC50: 5.56E+4nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetP2Y purinoceptor 6(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  6.50E+4nMAssay Description:Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to Escherichia coli KPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetEndoplasmin(Dog)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  2.10E+4nMAssay Description:Inhibition of BODIPY-AG binding to dog Grp94More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  69nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 5(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  1.80E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  1.00E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  2.80E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) 3 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 6(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  1.10E+4nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against recombinant human receptor P2X purinoceptor 2 (P2X2 )More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2Y purinoceptor 2(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50: >1.00E+5nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetHeat shock cognate 71 kDa protein(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  320nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetHeat shock cognate 71 kDa protein(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKd:  324nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  24nMAssay Description:Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Wild turkey)
Bar-Ilan University

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataEC50:  8.00E+3nMAssay Description:Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5'-nucleotidase(Rat)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKi:  0.910nMAssay Description:Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
Target2-dehydropantoate 2-reductase(Escherichia coli (strain K12))
University Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKi:  1.05E+6nMAssay Description:Inhibition of Escherichia coli KPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Smith Kline & French Research

Curated by ChEMBL
LigandPNGBDBM50368125(ADP | ADENOSINE DIPHOSPHATE)
Affinity DataKi:  1.00E+5nMAssay Description:Binding affinity (Ki) against human phosphatidylinositol 4-kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2019
Entry Details Article
PubMed