BDBM50378979 CHEMBL2011441

SMILES COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1

InChI Key InChIKey=TZYSLHTWOJFPSJ-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50378979   

TargetC-C chemokine receptor type 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataKd:  2.86E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 after 1 min by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataKd:  2.26E+4nMAssay Description:Binding affinity to C-terminus C9-tagged immobilized CCR5 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 63nMAssay Description:Antagonist activity at recombinant human CCR4 expressed in CHO-K1 cells assessed as inhibition of CCL22 induced Ca2+ mobilization after 2 hrs by FMAT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at mouse CCR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50378979(CHEMBL2011441)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at CCR4 in human primary Th2 cells by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2020
Entry Details Article
PubMed