BDBM50386790 CHEMBL1829174::CHEMBL2047159::TAK-875::US11905230, Example TAK-875

SMILES Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1

InChI Key InChIKey=BZCALJIHZVNMGJ-UHFFFAOYSA-N

Data  6 KI  4 IC50  2 Kd  48 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50386790   

TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at FFA1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human FFA1 expressed in CHO cells measured by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 4(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed