BDBM50443013 CHEMBL3087491

SMILES Cc1c(CNC(CO)CO)c(O)[nH]c(=O)c1C#N

InChI Key InChIKey=GDESQZDNNPOGEO-UHFFFAOYSA-N

Data  1 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443013   

TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443013BDBM50443013(CHEMBL3087491)
Affinity DataKd:  502nMAssay Description:Binding affinity to human recombinant UP1-inorganic phosphate binary complex expressed in Escherichia coli Rosetta (DE3) by isothermal titration calo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443013BDBM50443013(CHEMBL3087491)
Affinity DataKd:  5.30E+3nMAssay Description:Binding affinity to human recombinant UP1 expressed in Escherichia coli Rosetta (DE3) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443013BDBM50443013(CHEMBL3087491)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to human recombinant UP1-R1P binary complex expressed in Escherichia coli Rosetta (DE3) at 50 uM R1P by isothermal titration calorim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetUridine phosphorylase 1(Human)
Pontifical Catholic University of Rio Grande Do Sul

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443013BDBM50443013(CHEMBL3087491)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to human recombinant UP1-R1P binary complex expressed in Escherichia coli Rosetta (DE3) at 150 uM R1P by isothermal titration calori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed