BDBM50459819 CHEMBL4228445

SMILES CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NC)C1CC1

InChI Key InChIKey=JNYHQYRTYFSMSQ-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50459819   

TargetBromodomain-containing protein 4(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataKi:  0.5nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataKi:  1nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataIC50: 7nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL
LigandPNGBDBM50459819(CHEMBL4228445)
Affinity DataIC50: 7nMAssay Description:Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD4 bromodomain 2 (333 to 460 residues) (unknown origin) expressed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed