BDBM50466892 CHEMBL4283871
SMILES O=C(Nc1ccc2[nH]cc(C3CCN(CC3)C(=O)C3CCCC3)c2c1)c1cccc(c1)C#N
InChI Key InChIKey=HDYDGYGIQGBWPQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50466892
Affinity DataKi: 1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inverse agonist activity at RORA (unknown origin) assessed as inhibition of biotinylated co-activator SRC1-2 peptide recruitment after 3 hrs by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused RORB LBD (unknown origin) expressed in mouse neuro2A cells assessed as inhibition of transcriptional activity ...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inverse agonist activity at RORB (unknown origin) assessed as inhibition of biotinylated co-activator SRC1-2 peptide recruitment after 3 hrs by TR-FR...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inverse agonist activity at GAL4-fused RORC2 LBD (unknown origin) expressed in mouse neuro2A cells assessed as inhibition of transcriptional activity...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inverse agonist activity at GAL4-fused RORA LBD (unknown origin) expressed in mouse neuro2A cells assessed as inhibition of transcriptional activity ...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair