BDBM50501537 CHEMBL4085582
SMILES C=CC(=O)Nc1cccc(c1)-c1ncnc2[nH]ccc12
InChI Key InChIKey=FFMBRNVTWGVDHP-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50501537
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human His-tagged TYK2 expressed in baculovirus infected sf21 cells using 5FAM-KKSRGDYMTMQID as substrate in presence of 1 m...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK2 catalytic domain (809 to 1153+9 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK3 catalytic domain (781 to 1124 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.28E+3nMAssay Description:Inhibition of JAK3 in human whole blood assessed as inhibition of IL-15 induced STAT5 phosphorylation preincubated for 45 mins followed by IL-15 addi...More data for this Ligand-Target Pair
Affinity DataIC50: 8.71E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
Affinity DataIC50: 966nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of JAK3 in human PBMC assessed as inhibition of IL-15 induced STAT5 phosphorylation preincubated for 75 mins followed by IL-15 addition an...More data for this Ligand-Target Pair