BDBM525718 US11174252, Compound 13

SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CNCCc3c2)ncc1F

InChI Key InChIKey=FTWLELHFVFNVSG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 525718   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525718(US11174252, Compound 13)
Affinity DataIC50:  2nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525718(US11174252, Compound 13)
Affinity DataIC50:  2nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen™ Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525718(US11174252, Compound 13)
Affinity DataIC50:  1.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent