BDBM525768 US11174252, Compound 455
SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc3CCN(Cc3c2)C(=O)CN(C)C)ncc1F
InChI Key InChIKey=AYTDCXHHGYDWLU-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 525768
Affinity DataIC50: 4.5nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Nuvation Bio
US Patent
Nuvation Bio
US Patent
Affinity DataIC50: 1.31E+4nMAssay Description:PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 mM (pH7.5), Orthovanadate 3 mM, MgCl2 20 mM, DTT 2 mM, CHAPS 0.05%, DMSO 1%). PI...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:FMS: IC50 values of compounds against FMS kinase were determined by LanthaScreen Eu Kinase Binding Assay at Invitrogen (Life Technologies Grand...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair