BDBM525803 US11174252, Compound 495

SMILES CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2cc(no2)C2CCN(C)CC2)ncc1F

InChI Key InChIKey=WWUPNOVYRXPGJZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525803   

TargetCyclin-dependent kinase 4(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525803(US11174252, Compound 495)
Affinity DataIC50:  14nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525803(US11174252, Compound 495)
Affinity DataIC50:  2nMAssay Description:CDK5 (p25): IC50 values of compounds against CDK5 (p25) were determined by Z′-LYTE™. These screening assays were performed at Invitrogen L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

LigandPNGBDBM525803(US11174252, Compound 495)
Affinity DataIC50:  5nMAssay Description:CDK1 (cyclin B): IC50 values of compounds against CDK1 (cyclin B) were determined by Z′-LYTE™. These screening assays were performed at In...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetCyclin-dependent kinase 6(Human)
Nuvation Bio

US Patent
LigandPNGBDBM525803(US11174252, Compound 495)
Affinity DataIC50:  39nMAssay Description:CDK4 and CDK6: IC50 values of compounds against CDK4 and CDK6 were determined by luminescence using retinoblastoma as substrate. Kinase assays were p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent