BDBM538621 NCGC 00371481::US11254667, Compound I-24::US11542261, Compound I-24

SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1

InChI Key InChIKey=HTJGFHHVVPNDMR-UHFFFAOYSA-N

Data  24 IC50  13 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 538621   

TargetTyrosine-protein kinase Blk(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 538621BDBM538621(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Affinity DataIC50: 0.508nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetTyrosine-protein kinase Blk(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 538621BDBM538621(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Affinity DataIC50: 0.508nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent