BDBM569236 US11427563, Compound 103

SMILES Cc1cncc2ccc(NC(=O)[C@@H]3C[C@H]3c3ccc(cc3)S(=O)(=O)Nc3ccccn3)cc12

InChI Key InChIKey=IFYDROJSRZHNOS-XZOQPEGZSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 569236   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  4.5nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  0nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  1.90nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  5nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  0nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  0.950nMAssay Description:Compounds were prepared in the exact same manner as described in the ROCK Kinase Assay with the exception to the substrate and enzyme. The JAK 2× sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569236(US11427563, Compound 103)
Affinity DataIC50:  9nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent