BDBM8129 4-[(4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-yl)amino]benzonitrile::pyrazolo[1,5-b]pyridazine deriv. 20
SMILES N#Cc1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1
InChI Key InChIKey=YRSCDRTXWYUNBB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 8129
Affinity DataKi: 2nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex
Curated by ChEMBL
University Of Sussex
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of recombinant human N-terminal Hex-tagged DYRK1A (127 to 485 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair