Release Notes for 2026-02-05: Number of new affinity data: 7233 Number of compounds (ligands) new to BindingDB: 4011 Number of Targets new to BindingDB: 9 New Targets: Bromodomain testis-specific protein [267-376] (Q58F21[267-376]): 15 inhibitors Histone acetyltransferase KAT6A [497-780] (Q92794[497-780]): 79 inhibitors Histone acetyltransferase KAT6B [657-1069] (Q8WYB5[657-1069]): 79 inhibitors Histone deacetylase 1/8 (unmapped): 244 inhibitors Kelch-like ECH-associated protein 1/NAD(P)H dehydrogenase [quinone] 1/Nuclear factor erythroid 2-related factor 2 (unmapped): 93 inhibitors NAD(+) hydrolase SARM1 [28-724] (Q6SZW1[28-724]): 79 inhibitors Proto-oncogene tyrosine-protein kinase ROS (G2032R) (P08922[G2032R]): 19 inhibitors Shiga-like toxin 2 subunit A (P09385 ): 8 inhibitors Signal transducer and activator of transcription 6 [123-632] (P42226[123-632]): 13 inhibitors Number of new Entries: 43 PubMed id or Patent id Title US12419847 Composition and method for attenuating neuroinflammation, amyloidopathy and tauopathy US12419873 Use of JAK inhibitors in preparation of drugs for treating JAK kinase-related diseases US12419888 Methods of treating elevated plasma cholesterol US12421210 Fused bicyclic heterocycles as therapeutic agents US12421218 Substituted pyrazine-carboxamide derivatives US12421222 Substituted quinazolines as HDAC6 inhibitors US12421225 Heteroaromatic amide derivative and medicament containing the same US12421228 Naphthyridine derivatives as PRC2 inhibitors US12427135 Compositions and methods for inhibiting ribosome inactivating proteins US12427146 C-terminal SRC kinase inhibitors US12428395 Heterocyclic compounds as kinase inhibitor and uses thereof US12428423 1H-imidazo[4,5-h]quinazoline compound as protein kinase inhibitor US12428428 Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine US12428432 Thienopyrimidine derivatives having stereo configurations and use thereof in medicine US12428433 Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof US12435059 AMP-activated protein kinase inhibitors and methods of making and using the same US12435061 Compounds and compositions for use in treating skin disorders US12435062 Amide compounds and uses thereof US12435087 Modulators of DCN-1 and methods of use thereof US12435088 Salicyl-adenosinemonosulfamate analogs and uses thereof US12435089 3-oxadiazolyl substituted pyrazolo[1,5,a]pyrimidines for ROS1, NTRK, and ALK mediated diseases US12435090 Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use US12435095 Substituted morpholines as ATR kinase inhibitors US12435128 Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1 US20250295642 FLUOROQUINOXALINONE DERIVATIVE FOR SELECTIVELY INHIBITING PARP1 US20250296922 POLYSUBSTITUTED PYRROLIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF US20250296939 BENZOTHIOPHENE COMPOUND US20250299772 METHOD FOR GENERATION OF CHEMICAL DERIVATIVES AGAINST TARGET PROTEIN TO BUILD AI DRUG PLATFORM US20250302837 INHIBITORS OF CHYMASE FOR USE IN THE SELECTIVE RESOLUTION OF THROMBI IN THROMBOTIC OR THROMBOEMBOLIC DISORDERS US20250302842 HETEROCYCLIC COMPOUNDS USEFUL FOR TREATMENT OF CANCERS US20250304535 KAT6 Inhibitors US20250304537 HETEROARENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US20250304549 HYDROXYAMIDE DERIVATIVE AND USE THEREOF US20250304550 BROMODOMAIN AND EXTRA-TERMINAL (BET) SUBFAMILY BROMODOMAIN 1 (BD1) SELECTIVE INHIBITORS AND METHODS USING SAME US20250304563 ACTIVATORS OF EFFECTOR T CELLS US20250304568 PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE US20250304578 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS OF N-SULFONAMIDE AND USE THEREOF US20250304583 INHIBITING G CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP) US20250304585 SULFAMATE BASED COVALENT LIGAND-DIRECTED RELEASE (COLDR) COMPOUNDS US20250304587 WEE1 INHIBITOR, PREPARATION THEREFOR AND USE THEREOF WO2025045746 PYRAZOLE DERIVATIVES AS SARM1 INHIBITORS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS WO2025049274 TETRACYCLIC DERIVATIVES, COMPOSITIONS AND METHODS THEREOF WO2025049821 STAT6 DEGRADERS AND USES THEREOF