Release Notes for 2026-02-28: Number of new affinity data: 12176 Number of compounds (ligands) new to BindingDB: 7134 Number of Targets new to BindingDB: 12 New Targets: ALK tyrosine kinase receptor [I1171N,D1203N] (Q9UM73[I1171N,D1203N]): 40 inhibitors Baculoviral IAP repeat-containing protein 2 [184-250] (Q13490[184-250]): 164 inhibitors Baculoviral IAP repeat-containing protein 3 [169-235] (Q13489[169-235]): 162 inhibitors DNA polymerase theta [1-899] (O75417[1-899]): 271 inhibitors E3 ubiquitin-protein ligase XIAP [163-230] (P98170[163-230]): 129 inhibitors Endothelial PAS domain-containing protein 1 [230-300] (Q99814[230-300]): 4 inhibitors Fatty acid-binding protein, brain (FABP7) (O15540): 6 inhibitors Hypoxia-inducible factor 1-alpha [228-298] (Q16665): 58 inhibitors Interleukin-23 subunit alpha/receptor (unmapped): 51 inhibitors Myeloid cell surface antigen CD33 (P20138): 365 inhibitors Potassium sodium-activated channel subfamily T member 1 (C9J9Y7): 651 inhibitors Number of new Entries: 65 PubMed id or Patent id Title US12440481 Esters and carbamates as modulators of sodium channels US12440484 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same US12440494 Compounds useful for inhibiting RAF dimers US12441689 ACSS2 inhibitors and methods of use thereof US12441690 Benzamide derivative compound, method for preparing same, and pharmaceutical composition for treating or preventing inflammatory disease containing same as active ingredient US12441703 Carboxamides as modulators of sodium channels US12441707 Indazole compounds US12441708 Cereblon ligands and bifunctional compounds comprising the same US12441734 Ferroptosis inhibitor and use therefor US12447151 Alkyne derivative, preparation method for same, and uses thereof US12447153 HER2 mutation inhibitors US12448359 Compounds with immunomodulatory activity and therapeutic uses thereof US12448364 2, 4-diaminopyrimidine derivative and application thereof US12448365 Aryl aminopyrimidines as dual MerTK and TYRO3 inhibitors and methods thereof US12448378 Fluoropyrrolopyridine compound and application thereof US12453731 Aniline-based WDR5 protein-protein interaction inhibitor, and preparation method and use thereof US12454524 (r)-n-(4-(chlorodifluoromethoxy)phenyl)-2-(difluoromethyl)-1-(1-hydroxypropan-2-yl)-7-(pyrimidin-5-yl)-1H-benzo[d]imidazole-5-carboxamide, or a pharmaceutically acceptable salt or tautomer thereof, for treating certain leukemias US12454530 Amido cyclohexane acid derivatives as LPA receptor inhibitors US12454531 Substituted piperazine derivatives useful as T cell activators US12458627 Autotaxin inhibitors and uses thereof US12458640 Pyrazolo[3,4-b]pyrazine SHP2 phosphatase inhibitors US12459899 Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient US12459915 Biaryl derivative useful as diacylglycerol acyltransferase 2 inhibitor, and use thereof US12459916 Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals US12459931 Benzothiophene derivative regulator, preparation method therefor and use thereof US12459956 Heterobicyclic carboxamides and uses thereof US20250313548 HETEROCYCLIC COMPOUNDS USEFUL AS KCNT1 INHIBITORS US20250313563 GLYCOGEN SYNTHASE KINASE 3 INHIBITORS AND USES THEREOF US20250313574 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME US20250319046 PHENYLALANINE-BASED LAT1 INHIBITORS AND USES THEREOF US20250319096 METHODS AND COMPOUNDS FOR TREATING INFLAMMATION US20250320193 OXOISOINDOLINYL SUBSTITUTED PIPERIDINEDIONE DERIVATIVE AND USE THEREOF US20250320228 PYRIDO[3,2-D]PYRIMIDINES AS HPK1 INHIBITORS US20250320233 ARGINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME US20250320234 LONP1 INHIBITOR COMPOUNDS, USES AND METHODS US20250325529 INHIBITORS OF FATTY ACID BINDING PROTEINS (FABPs), METHODS OF USE AND METHODS OF MAKING US20250325542 INHIBITORS OF ANTIMOCROBIAL RESISTANCE AND METHOS USING SAME US20250325552 SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS US20250325677 STAT6 DEGRADERS US20250325711 COVALENT FLUORESCENT PROBES FOR CANNABINOID RECEPTOR 2 US20250326722 NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF US20250326732 CHROMEN-2-ONE MODULATORS OF POLRMT US20250326739 CD38 MODULATORS AND USES THEREOF US20250326754 DNA-PK Inhibitor Compounds and Uses Thereof US20250326769 HETEROAROMATIC MACROCYCLIC ETHER CHEMOTHERAPEUTIC AGENTS US20250326771 PIPERAZINE DERIVATIVES USEFUL IN HIV THERAPY US20250326790 PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE US20250332138 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MENTAL DISORDER US20250333393 HETEROCYCLIC COMPOUND AS TYK2 INHIBITOR, AND SYNTHESIS AND USE THEREOF US20250333394 Tiparp Inhibitor Compounds US20250333404 DEUTERATED COMPOUNDS US20250333409 Compound and use thereof in preparation of BCL-XL inhibitor US20250333410 COMPOUND FOR INHIBITING OR DEGRADING BCL6 AND USE THEREOF IN PHARMACEUTICS US20250340516 Isoquinolinones as Modulators of POLRMT US20250340529 Heterocyclic Compounds as Immunomodulators of PD-L1 Interactions US20250340530 GCN2 INHIBITOR (as amended) US20250340543 GPR84 ANTAGONISTS AND USES THEREOF US20250340546 HSD17B13 INHIBITORS US20250340551 SMALL MOLECULE MODULATORS OF STAT6 US20250340556 PYRIMIDOPYRIMIDONE COMPOUNDS AND METHODS OF USE THEREOF US20250340560 SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS US20250340565 CD73 INHIBITOR COMPOUNDS US20250340886 INTRACELLULAR KINASE ASSOCIATED WITH RESISTANCE AGAINST ANTI-TUMOUR IMMUNE RESPONSES, AND USES THEREOF WO2025051920 NEW PEPTIDES AS SELECTIVE IL-23 RECEPTOR INHIBITORS WO2025054369 COMPOUNDS, COMPOSITIONS, AND METHODS