Release Notes for 2026-05-25: Number of new affinity data: 5990 Number of compounds (ligands) new to BindingDB: 4131 Number of Targets new to BindingDB: 17 New Targets: Autotaxin/Lysophosphatidic acid receptor 2 (Q13822,Q9HBW0): 36 inhibitors CREB-binding protein [1085-1192] (Q92793[1085-1192]): 8 inhibitors Choline trimethylamine-lyase/Choline trimethylamine-lyase activating enzyme (B4EYG1,B4EYG0): 5 inhibitors E3 ubiquitin-protein ligase TRIM21 (P19474): 58 inhibitors HLA-DR4 protein (O77963): 253 inhibitors Histone acetyltransferase p300 [1049-1156] (Q09472[1049-1156]): 8 inhibitors Mitogen-activated protein kinase 1/Myeloid differentiation primary response protein MyD88 [24-40] (Q99836[24-40],P28482): 4 inhibitors Mitogen-activated protein kinase 3/MAMyeloid differentiation primary response protein MyD88 [24-40] (Q99836[24-40],P27361): 4 inhibitors Non-receptor tyrosine-protein kinase TYK2 [897-1176] (P29597[897-1176]): 1 inhibitors Progesterone receptor ligand binding domain (LBD) (P06401): 23 inhibitors Protein cereblon [318-426] (Q96SW2[318-426]): 311 inhibitors Steroid hormone receptor ERR1 LBD (P11474): 46 inhibitors Thiamine pyrophosphokinase 1 (Q9H3S4): 76 inhibitors Tyrosine-protein kinase JAK1 [875-1153] (P23458[875-1153]): 1 inhibitors Tyrosine-protein kinase JAK2 [549-809] (O60674[549-809]): 1 inhibitors Tyrosine-protein kinase JAK3 [822-1111] (P52333[822-1111]): 1 inhibitors cyp2d6 (P10635): 2 inhibitors Number of new Entries: 56 PubMed id or Patent id Title US12496348 Small molecule target bromo/acetyl proteins and uses thereof US12497392 EP300/CBP inhibitor US12497405 Bicyclic heterocycle compounds methods of use thereof for the treatment of herpes viruses US12503453 USP7 inhibition US12503484 Androstane derivatives with activity as pure or predominantly pure stimulators of SERCA2a for the treatment of heart failure US12509424 Compound and composition as PDGF receptor kinase inhibitor US12509446 FYN and VEGFR2 kinase inhibitors US12509454 Thiadiazolyl derivatives US12509465 Benzoimidazole derivatives as anticancer agents US12514858 CD38 inhibitors US12516038 Inhibitors of antigen presentation by HLA-DR US12516046 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors US12516054 Pyrazolo[1,5-a]pyridine derivatives, preparation method therefor and use thereof US20250381168 VLA4 INHIBITORS AND USES THEREOF US20250381196 ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KIDNEY DISEASES AND KIDNEY-RELATED DISEASES US20250382276 COMPOUND, METHOD OF PREPARATION, COMPOSITION, AND USES THEREOF US20250382289 PYRAZOLOPYRIDINE DERIVATIVE AND APPLICATION THEREOF IN MEDICINE US20250382297 INHIBITORS OF FGFR2 AND FGFR3 AND USES THEREOF US20250382298 NITROGEN-CONTAINING COMPOUND AND USE THEREOF US20250382308 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS US20250387379 ARYL-ANILINE AND HETEROARYL-ANILINE COMPOUNDS FOR TREATMENT OF SKIN CANCERS US20250387388 COMPOUND AS TRK INHIBITOR AND/OR RET INHIBITOR AND USE THEREOF US20250387403 SELECTIVE SIGMA-2 RECEPTOR LIGANDS AS MODULATORS OF TMEM97 US20250388553 AMINOPYRAZINE DERIVATIVES AS PI3K-y INHIBITORS US20250388560 AROMATIC COMPOUND AND USE THEREOF US20250388567 SELECTIVE G PROTEIN-COUPLED RECEPTOR KINASE 5 INHIBITORS, COMPOSITIONS, AND METHODS OF USE US20250388573 FUSED BICYCLIC EGFR INHIBITORS AND METHODS OF USE THEREOF US20250388575 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE US20250388576 PYRIDONOPYRIMIDINE DERIVATIVE AS RSK INHIBITOR AND USE THEREOF US20250388583 COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION US20250388584 TPK AGONIST AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES USING SAME US20250388589 TRICYCLIC HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF US20250388593 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR US20250388602 Tetrahydropyranopyrazole Derivatives for the Treatment of Cancer and Viral Infections US20260000676 CHROMAN DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS US20260001833 COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING PRODUCTION OF TRIMETHYLAMINE US20260001863 NOVEL PYRIDAZINES US20260001864 COMPOUND CONTAINING SULFAMIDE STRUCTURE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION US20260001868 HETEROCYCLIC COMPOUND CAPABLE OF INHIBITING PRMT5-MTA AND USE THEREOF US20260001879 COMPOUNDS AS MYT1 INHIBITORS US20260001881 COMPOUNDS AND METHODS FOR MODULATION OF G-PROTEIN-COUPLED RECEPTORS US20260001884 Heterocycle compounds for the treatment of cancer US20260001886 ENPP1 INHIBITORS I US20260001887 CYCLIN-DEPENDENT KINASE INHIBITORS US20260001888 PYRAZOLOPYRIMIDINE PDE9 INHIBITORS US20260001892 COMPOUND FOR REGULATING AND CONTROLLING ACTIVITY OF 15-PGDH AND PREPARATION METHOD THEREFOR US20260001898 Heteroaryl compounds as inhibitors of TYK2/JAK1, composition and application thereof US20260007675 TARGETING CHROMATIN REGULATORS INHIBITS LEUKEMOGENIC GENE EXPRESSION IN NPM1 MUTANT LEUKEMIA US20260007681 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS US20260007684 AMIDE DERIVATIVES FOR INHIBITING NLRP3 AND USES THEREOF US20260007787 RADIOPHARMACEUTICAL SMALL MOLECULE INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN FOR TARGETED THERAPY AND DIAGNOSTIC IMAGING OF DESMOPLASTIC TUMORS US20260008750 COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING PRODUCTION OF TRIMETHYLAMINE US20260008758 LINEAR DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF US20260008770 CBL-B INHIBITORS AND METHODS OF USES THEREOF US20260008771 PYRIDAZINE BASED SMALL MOLECULE INHIBITOR OF COGNITIVE IMPAIRMENT US20260008775 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION