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Found 43 Enz. Inhib. hit(s) with Target = 'Secreted chorismate mutase'
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50209967(4-[2-(3,4-dimethoxy-phenyl)-ethylamino]-3-nitro-5-...)
Affinity DataKi:  5.70E+3nMAssay Description:Inhibition of chorismate mutase in Mycobacterium tuberculosis H37Rv strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50209968((Z)-2-(4-chlorophenyl)-3-(4,5-dimethoxy-2-nitrophe...)
Affinity DataKi:  1.77E+4nMAssay Description:Inhibition of chorismate mutase in Mycobacterium tuberculosis H37Rv strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50209969(2-(3-(tert-butoxycarbonyl)-2-phenylthiazolidine-4-...)
Affinity DataKi:  2.11E+4nMAssay Description:Inhibition of chorismate mutase in Mycobacterium tuberculosis H37Rv strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50209966(CHEMBL242816 | methyl 4-(methylamino)-3-nitrobenzo...)
Affinity DataKi:  2.88E+4nMAssay Description:Inhibition of chorismate mutase in Mycobacterium tuberculosis H37Rv strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108084(3-((5-nitrothiophen-2-yl)methylene)indolin-2-one (...)
Affinity DataIC50:  930nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM22787(1-acetyl-2,3-dihydro-1H-indole-2,3-dione | Acetyli...)
Affinity DataIC50:  990nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108083(3-(4-nitrobenzylidene)indolin-2-one (Compound 24))
Affinity DataIC50:  1.01E+3nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50240433(5-Isopropyl-2-methyl-phenol | CARVACROL | CHEMBL28...)
Affinity DataIC50:  1.06E+3nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM11022(2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | I...)
Affinity DataIC50:  1.08E+3nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL6...)
Affinity DataIC50:  1.96E+3nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248169(Thymol derivative, 17)
Affinity DataIC50:  4.08E+3nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248165(Carvacrol derivative, 8)
Affinity DataIC50:  1.16E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248163((±)Neo isopulegol)
Affinity DataIC50:  1.36E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248168(Carvacrol derivative, 15)
Affinity DataIC50:  1.37E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50363851(CHEMBL1945938)
Affinity DataIC50:  1.97E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis chorismate mutase expressed in Escherichia coli BL21 assessed as conversion of chorismate to prephenate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248167(Carvacrol derivative, 10)
Affinity DataIC50:  2.14E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248170(Thymol derivative, 21)
Affinity DataIC50:  2.16E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108065(1‐ethylindole‐2,3‐dione (Compoun...)
Affinity DataIC50:  2.27E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248166(Carvacrol derivative, 9)
Affinity DataIC50:  2.31E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM22793(1‐phenylindole‐2,3‐dione (Compou...)
Affinity DataIC50:  2.33E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50177405(3-methoxy-4-hydroxybenzaldehyde | 4-hydroxy-3-meth...)
Affinity DataIC50:  2.48E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108072(1‐[(3Z)‐1‐acetyl‐2‐o...)
Affinity DataIC50:  2.50E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108081(5‐(piperidin‐1‐yl)‐1H̴...)
Affinity DataIC50:  2.56E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248162(Menthol)
Affinity DataIC50:  2.64E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM248164(Carvacrol derivative, 7)
Affinity DataIC50:  2.68E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50240432(1-hydroxy-5-methyl-2-isopropylbenzene | 2-isopropy...)
Affinity DataIC50:  2.84E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50164168(1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...)
Affinity DataIC50:  2.86E+4nMpH: 7.5 T: 2°CAssay Description:Reaction volumes of 0.4 mL of chorismate (typically, 1 mM) in 50 mM Tris-HCl (pH 7.5), 0.5 mM EDTA, 0.1 mg/mL bovine serum albumin, and 10 mM β-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108082(5‐[4‐(furan‐2‐carbonyl)pip...)
Affinity DataIC50:  2.88E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108071(1‐[(3Z)‐1‐acetyl‐2‐o...)
Affinity DataIC50:  3.05E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108079(5‐(4‐methylpiperazin‐1‐yl)...)
Affinity DataIC50:  3.19E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108077(5‐(2,5‐dimethylphenyl)‐1H‐...)
Affinity DataIC50:  3.65E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50334290(5‐phenyl‐1H‐indole‐2,3R...)
Affinity DataIC50:  3.71E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108078(5‐(piperazin‐1‐yl)‐1H̴...)
Affinity DataIC50:  3.99E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108068(1‐(2,2‐dimethylpropanoyl)indole‐...)
Affinity DataIC50:  4.10E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108070(3‐amino‐1‐[(3Z)‐2‐ox...)
Affinity DataIC50:  5.41E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108080(5‐{4‐[3‐(trifluoromethyl)phenyl]...)
Affinity DataIC50:  5.57E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108069(3‐amino‐1‐[(3Z)‐2‐ox...)
Affinity DataIC50:  6.69E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108066(1‐isopropylindole‐2,3‐dione (Com...)
Affinity DataIC50:  7.51E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108076(5‐(2,3‐dichlorophenyl)‐1H‐...)
Affinity DataIC50:  9.57E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108067(1‐(prop‐2‐en‐1‐yl)in...)
Affinity DataIC50:  9.66E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108075((3Z)‐3‐(hydroxyimino)‐1H‐i...)
Affinity DataIC50:  9.81E+4nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108073((3Z)‐3‐[(5‐nitro‐1,3‐...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSecreted chorismate mutase(Mycobacterium tuberculosis H37Rv)
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM108074((3Z)‐3‐[(6‐nitro‐1,3‐...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:The reaction was initiated by the addition of 150pmoles of enzyme to a mixture of inhibitor (40µM, 20 µM, 10 µM, 5 µM, 1 µM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed