KEGG   Homo sapiens (human): 10257
Entry
10257             CDS       T01001                                 
Symbol
ABCC4, MOAT-B, MOATB, MRP4
Name
(RefSeq) ATP binding cassette subfamily C member 4 (PEL blood group)
  KO
K05673  ATP-binding cassette, subfamily C (CFTR/MRP), member 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa01523  Antifolate resistance
hsa02010  ABC transporters
hsa04024  cAMP signaling pathway
hsa04976  Bile secretion
hsa04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    10257 (ABCC4)
  09132 Signal transduction
   04024 cAMP signaling pathway
    10257 (ABCC4)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    10257 (ABCC4)
   04981 Folate transport and metabolism
    10257 (ABCC4)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    10257 (ABCC4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    10257 (ABCC4)
Transporters [BR:hsa02000]
 ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC1, 2, 3, 4, 5, 6, 10, 11, 12, 13 subgroups
    10257 (ABCC4)
SSDB
Motif
Pfam: ABC_membrane ABC_tran SMC_N AAA_16 AAA_29 MMR_HSR1 nSTAND1 RsgA_GTPase AAA_22 Dynamin_N AAA_23 ABC_ATPase DUF87
Other DBs
NCBI-GeneID: 10257
NCBI-ProteinID: NP_005836
OMIM: 605250
HGNC: 55
Ensembl: ENSG00000125257
UniProt: O15439 A8K2Q2
Structure
Position
13:complement(95019835..95301451)
AA seq 1325 aa
MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEEL
QGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYF
ENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALR
LSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAG
MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLIT
NLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGA
VRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD
KASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQ
QPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK
ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAA
SQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVW
SQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL
NTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGI
ARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTF
LDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPV
FSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFV
IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE
KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAG
KSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNE
HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILII
DEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYV
LLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTI
FETAL
NT seq 3978 nt   +upstreamnt  +downstreamnt
atgctgcccgtgtaccaggaggtgaagcccaacccgctgcaggacgcgaacctctgctca
cgcgtgttcttctggtggctcaatcccttgtttaaaattggccataaacggagattagag
gaagatgatatgtattcagtgctgccagaagaccgctcacagcaccttggagaggagttg
caagggttctgggataaagaagttttaagagctgagaatgacgcacagaagccttcttta
acaagagcaatcataaagtgttactggaaatcttatttagttttgggaatttttacgtta
attgaggaaagtgccaaagtaatccagcccatatttttgggaaaaattattaattatttt
gaaaattatgatcccatggattctgtggctttgaacacagcgtacgcctatgccacggtg
ctgactttttgcacgctcattttggctatactgcatcacttatatttttatcacgttcag
tgtgctgggatgaggttacgagtagccatgtgccatatgatttatcggaaggcacttcgt
cttagtaacatggccatggggaagacaaccacaggccagatagtcaatctgctgtccaat
gatgtgaacaagtttgatcaggtgacagtgttcttacacttcctgtgggcaggaccactg
caggcgattgcagtgactgccctactctggatggagataggaatatcgtgccttgctggg
atggcagttctaatcattctcctgcccttgcaaagctgttttgggaagttgttctcatca
ctgaggagtaaaactgcaactttcacggatgccaggatcaggaccatgaatgaagttata
actggtataaggataataaaaatgtacgcctgggaaaagtcattttcaaatcttattacc
aatttgagaaagaaggagatttccaagattctgagaagttcctgcctcagagggatgaat
ttggcttcatttttcagtgcaagcaaaatcatcgtgtttgtgaccttcaccacctacgtg
ctcctcggcagtgtgatcacagccagccgcgtgttcgtggcagtgacgctgtatggggct
gtgcggctgacggttaccctcttcttcccctcagccattgagagggtgtcagaggcaatc
gtcagcatccgaagaatccagacctttttgctacttgatgagatatcacagcgcaaccgt
cagctgccgtcagatggtaaaaagatggtgcatgtgcaggattttactgctttttgggat
aaggcatcagagaccccaactctacaaggcctttcctttactgtcagacctggcgaattg
ttagctgtggtcggccccgtgggagcagggaagtcatcactgttaagtgccgtgctcggg
gaattggccccaagtcacgggctggtcagcgtgcatggaagaattgcctatgtgtctcag
cagccctgggtgttctcgggaactctgaggagtaatattttatttgggaagaaatacgaa
aaggaacgatatgaaaaagtcataaaggcttgtgctctgaaaaaggatttacagctgttg
gaggatggtgatctgactgtgataggagatcggggaaccacgctgagtggagggcagaaa
gcacgggtaaaccttgcaagagcagtgtatcaagatgctgacatctatctcctggacgat
cctctcagtgcagtagatgcggaagttagcagacacttgttcgaactgtgtatttgtcaa
attttgcatgagaagatcacaattttagtgactcatcagttgcagtacctcaaagctgca
agtcagattctgatattgaaagatggtaaaatggtgcagaaggggacttacactgagttc
ctaaaatctggtatagattttggctcccttttaaagaaggataatgaggaaagtgaacaa
cctccagttccaggaactcccacactaaggaatcgtaccttctcagagtcttcggtttgg
tctcaacaatcttctagaccctccttgaaagatggtgctctggagagccaagatacagag
aatgtcccagttacactatcagaggagaaccgttctgaaggaaaagttggttttcaggcc
tataagaattacttcagagctggtgctcactggattgtcttcattttccttattctccta
aacactgcagctcaggttgcctatgtgcttcaagattggtggctttcatactgggcaaac
aaacaaagtatgctaaatgtcactgtaaatggaggaggaaatgtaaccgagaagctagat
cttaactggtacttaggaatttattcaggtttaactgtagctaccgttctttttggcata
gcaagatctctattggtattctacgtccttgttaactcttcacaaactttgcacaacaaa
atgtttgagtcaattctgaaagctccggtattattctttgatagaaatccaataggaaga
attttaaatcgtttctccaaagacattggacacttggatgatttgctgccgctgacgttt
ttagatttcatccagacattgctacaagtggttggtgtggtctctgtggctgtggccgtg
attccttggatcgcaatacccttggttccccttggaatcattttcatttttcttcggcga
tattttttggaaacgtcaagagatgtgaagcgcctggaatctacaactcggagtccagtg
ttttcccacttatcatcttctctccaggggctctggaccatccgggcatacaaagcagaa
gagaggtgtcaggaactgtttgatgcacaccaggatttacattcagaggcttggttcttg
tttttgacaacgtcccgctggtttgccgtccgtctggatgccatctgtgccatgtttgtc
atcatcgttgcctttgggtccctgattctggcaaaaactctggatgccgggcaggttggt
ttggcactgtcctatgccctcacgctcatggggatgtttcagtggtgtgttcgacaaagt
gctgaagttgagaatatgatgatctcagtagaaagggtcattgaatacacagaccttgaa
aaagaagcaccttgggaatatcagaaacgcccaccaccagcctggccccatgaaggagtg
ataatctttgacaatgtgaacttcatgtacagtccaggtgggcctctggtactgaagcat
ctgacagcactcattaaatcacaagaaaaggttggcattgtgggaagaaccggagctgga
aaaagttccctcatctcagccctttttagattgtcagaacccgaaggtaaaatttggatt
gataagatcttgacaactgaaattggacttcacgatttaaggaagaagatgtcaatcata
cctcaggaacctgttttgttcactggaacaatgaggaaaaacctggatccctttaatgag
cacacggatgaggaactgtggaatgccttacaagaggtacaacttaaagaaaccattgaa
gatcttcctggtaaaatggatactgaattagcagaatcaggatccaattttagtgttgga
caaagacaactggtgtgccttgccagggcaattctcaggaaaaatcagatattgattatt
gatgaagcgacggcaaatgtggatccaagaactgatgagttaatacaaaaaaaaatccgg
gagaaatttgcccactgcaccgtgctaaccattgcacacagattgaacaccattattgac
agcgacaagataatggttttagattcaggaagactgaaagaatatgatgagccgtatgtt
ttgctgcaaaataaagagagcctattttacaagatggtgcaacaactgggcaaggcagaa
gccgctgccctcactgaaacagcaaaacaggtatacttcaaaagaaattatccacatatt
ggtcacactgaccacatggttacaaacacttccaatggacagccctcgaccttaactatt
ttcgagacagcactgtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (56)   
   RefSeq(nuc) (10)   
   GenBank (23)   
   EMBL (23)   
3D Structure (17)   
   PDB (17)   
Protein domain (13)   
   Pfam (13)   
All databases (118)   

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