Entry |
|
Symbol |
FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
|
Name |
(RefSeq) fibroblast growth factor receptor 2
|
KO |
|
Organism |
|
Pathway |
hsa01521 | EGFR tyrosine kinase inhibitor resistance |
hsa04550 | Signaling pathways regulating pluripotency of stem cells |
hsa04810 | Regulation of actin cytoskeleton |
hsa05230 | Central carbon metabolism in cancer |
|
Network |
|
Element |
N00019 | FGF-FGFR-RAS-ERK signaling pathway |
N00020 | Amplified FGFR to RAS-ERK signaling pathway |
N00037 | FGF-FGFR-PI3K signaling pathway |
N00038 | Amplified FGFR to PI3K signaling pathway |
N01592 | GF-RTK-RAS-ERK signaling pathway |
N01599 | Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL |
N01641 | RTK-PLCG-ITPR signaling pathway |
N01656 | GF-RTK-PI3K signaling pathway |
N01658 | GF-RTK-RAS-PI3K signaling pathway |
|
Disease |
H00458 | Syndromic craniosynostoses |
H00642 | Lacrimo-auriculo-dento-digital syndrome |
H01989 | Beare-Stevenson syndrome |
H01991 | Saethre-Chotzen syndrome |
H02629 | Bent bone dysplasia syndrome |
|
Drug target |
Derazantinib hydrochloride: | D11461 |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
2263 (FGFR2)
04014 Ras signaling pathway
2263 (FGFR2)
04015 Rap1 signaling pathway
2263 (FGFR2)
04020 Calcium signaling pathway
2263 (FGFR2)
04151 PI3K-Akt signaling pathway
2263 (FGFR2)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
2263 (FGFR2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
2263 (FGFR2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
2263 (FGFR2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2263 (FGFR2)
05230 Central carbon metabolism in cancer
2263 (FGFR2)
09162 Cancer: specific types
05226 Gastric cancer
2263 (FGFR2)
05215 Prostate cancer
2263 (FGFR2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
2263 (FGFR2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
2263 (FGFR2)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:hsa04090]
2263 (FGFR2)
00536 Glycosaminoglycan binding proteins [BR:hsa00536]
2263 (FGFR2)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
2263 (FGFR2)
Protein kinases [BR:hsa01001]
Receptor tyrosine kinases (RTK)
FGFR family [OT]
2263 (FGFR2)
CD molecules [BR:hsa04090]
Proteins
2263 (FGFR2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
Growth factors/receptors
2263 (FGFR2)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
10:complement(121478330..121598458)
|
AA seq |
821 aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT |
NT seq |
2466 nt +upstreamnt +downstreamnt
atggtcagctggggtcgtttcatctgcctggtcgtggtcaccatggcaaccttgtccctg
gcccggccctccttcagtttagttgaggataccacattagagccagaagagccaccaacc
aaataccaaatctctcaaccagaagtgtacgtggctgcgccaggggagtcgctagaggtg
cgctgcctgttgaaagatgccgccgtgatcagttggactaaggatggggtgcacttgggg
cccaacaataggacagtgcttattggggagtacttgcagataaagggcgccacgcctaga
gactccggcctctatgcttgtactgccagtaggactgtagacagtgaaacttggtacttc
atggtgaatgtcacagatgccatctcatccggagatgatgaggatgacaccgatggtgcg
gaagattttgtcagtgagaacagtaacaacaagagagcaccatactggaccaacacagaa
aagatggaaaagcggctccatgctgtgcctgcggccaacactgtcaagtttcgctgccca
gccggggggaacccaatgccaaccatgcggtggctgaaaaacgggaaggagtttaagcag
gagcatcgcattggaggctacaaggtacgaaaccagcactggagcctcattatggaaagt
gtggtcccatctgacaagggaaattatacctgtgtagtggagaatgaatacgggtccatc
aatcacacgtaccacctggatgttgtggagcgatcgcctcaccggcccatcctccaagcc
ggactgccggcaaatgcctccacagtggtcggaggagacgtagagtttgtctgcaaggtt
tacagtgatgcccagccccacatccagtggatcaagcacgtggaaaagaacggcagtaaa
tacgggcccgacgggctgccctacctcaaggttctcaaggccgccggtgttaacaccacg
gacaaagagattgaggttctctatattcggaatgtaacttttgaggacgctggggaatat
acgtgcttggcgggtaattctattgggatatcctttcactctgcatggttgacagttctg
ccagcgcctggaagagaaaaggagattacagcttccccagactacctggagatagccatt
tactgcataggggtcttcttaatcgcctgtatggtggtaacagtcatcctgtgccgaatg
aagaacacgaccaagaagccagacttcagcagccagccggctgtgcacaagctgaccaaa
cgtatccccctgcggagacaggtaacagtttcggctgagtccagctcctccatgaactcc
aacaccccgctggtgaggataacaacacgcctctcttcaacggcagacacccccatgctg
gcaggggtctccgagtatgaacttccagaggacccaaaatgggagtttccaagagataag
ctgacactgggcaagcccctgggagaaggttgctttgggcaagtggtcatggcggaagca
gtgggaattgacaaagacaagcccaaggaggcggtcaccgtggccgtgaagatgttgaaa
gatgatgccacagagaaagacctttctgatctggtgtcagagatggagatgatgaagatg
attgggaaacacaagaatatcataaatcttcttggagcctgcacacaggatgggcctctc
tatgtcatagttgagtatgcctctaaaggcaacctccgagaatacctccgagcccggagg
ccacccgggatggagtactcctatgacattaaccgtgttcctgaggagcagatgaccttc
aaggacttggtgtcatgcacctaccagctggccagaggcatggagtacttggcttcccaa
aaatgtattcatcgagatttagcagccagaaatgttttggtaacagaaaacaatgtgatg
aaaatagcagactttggactcgccagagatatcaacaatatagactattacaaaaagacc
accaatgggcggcttccagtcaagtggatggctccagaagccctgtttgatagagtatac
actcatcagagtgatgtctggtccttcggggtgttaatgtgggagatcttcactttaggg
ggctcgccctacccagggattcccgtggaggaactttttaagctgctgaaggaaggacac
agaatggataagccagccaactgcaccaacgaactgtacatgatgatgagggactgttgg
catgcagtgccctcccagagaccaacgttcaagcagttggtagaagacttggatcgaatt
ctcactctcacaaccaatgaggaatacttggacctcagccaacctctcgaacagtattca
cctagttaccctgacacaagaagttcttgttcttcaggagatgattctgttttttctcca
gaccccatgccttacgaaccatgccttcctcagtatccacacataaacggcagtgttaaa
acatga |