KEGG   Homo sapiens (human): 6196
Entry
6196              CDS       T01001                                 
Symbol
RPS6KA2, HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, p90RSK2, pp90RSK3
Name
(RefSeq) ribosomal protein S6 kinase A2
  KO
K04373  ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04114  Oocyte meiosis
hsa04150  mTOR signaling pathway
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04722  Neurotrophin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04931  Insulin resistance
hsa05135  Yersinia infection
hsa05207  Chemical carcinogenesis - receptor activation
Network
nt06526  MAPK signaling
  Element
N01601  ERK-RSK signaling
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    6196 (RPS6KA2)
 09150 Organismal Systems
  09156 Nervous system
   04720 Long-term potentiation
    6196 (RPS6KA2)
   04722 Neurotrophin signaling pathway
    6196 (RPS6KA2)
  09159 Environmental adaptation
   04714 Thermogenesis
    6196 (RPS6KA2)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    6196 (RPS6KA2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    6196 (RPS6KA2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    6196 (RPS6KA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    6196 (RPS6KA2)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    6196 (RPS6KA2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     6196 (RPS6KA2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   6196 (RPS6KA2)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     6196 (RPS6KA2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Kdo Pkinase_fungal Pkinase_C APH YrbL-PhoP_reg RIO1 Haspin_kinase
Other DBs
NCBI-GeneID: 6196
NCBI-ProteinID: NP_066958
OMIM: 601685
HGNC: 10431
Ensembl: ENSG00000071242
UniProt: Q15349
Position
6:complement(166409364..166862773)
AA seq 733 aa
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
QRRGMKRLTSTRL
NT seq 2202 nt   +upstreamnt  +downstreamnt
atggacctgagcatgaagaagttcgccgtgcgcaggttcttctctgtgtacctgcgcagg
aagtcgcgctccaagagctccagcctgagccggctcgaggaagaaggcgtcgtgaaggag
atagacatcagccatcatgtgaaggagggctttgagaaggcagatccttcccagtttgag
ctgctgaaggttttaggacaaggatcctatggaaaggtgttcctggtgaggaaggtgaag
gggtccgacgctgggcagctctacgccatgaaggtccttaagaaagccaccctaaaagtt
cgggaccgagtgagatcgaagatggagagagacatcttggcagaagtgaatcaccccttc
attgtgaagcttcattatgcctttcagacggaaggaaagctctacctgatcctggacttc
ctgcggggaggggacctcttcacccggctctccaaagaggtcatgttcacggaggaggat
gtcaagttctacctggctgagctggccttggctttagaccatctccacagcctggggatc
atctacagagatctgaagcctgagaacatcctcctggatgaagaggggcacattaagatc
acagatttcggcctgagtaaggaggccattgaccacgacaagagagcgtactccttctgc
gggacgatcgagtacatggcgcccgaggtggtgaaccggcgaggacacacgcagagtgcc
gactggtggtccttcggcgtgctcatgtttgagatgctcacggggtccctgccgttccag
gggaaggacaggaaggagaccatggctctcatcctcaaagccaagctggggatgccgcag
ttcctcagtggggaggcacagagtttgctgcgagctctcttcaaacggaacccctgcaac
cggctgggtgctggcattgacggagtggaggaaattaagcgccatcccttctttgtgacc
atagactggaacacgctgtaccggaaggagatcaagccaccgttcaaaccagcagtgggc
aggcctgaggacaccttccactttgaccccgagttcacagcgcggacgcccacagactct
cctggcgtccccccgagtgcaaacgctcatcacctgtttagaggattcagctttgtggcc
tcaagcctgatccaggagccctcacagcaagatctgcacaaagtcccagttcacccaatc
gtgcagcagttacacgggaacaacatccacttcaccgatggctacgagatcaaggaggac
atcggggtgggctcctactcagtgtgcaagcgatgtgtgcataaagccacagacaccgag
tatgccgtgaagatcattgataagagcaagagagacccctcggaagagattgagatcctc
ctgcggtacggccagcacccgaacatcatcaccctcaaggatgtctatgatgatggcaag
tttgtgtacctggtaatggagctgatgcgtggtggggagctcctggaccgcatcctccgg
cagagatacttctcggagcgcgaagccagtgacgtcctgtgcaccatcaccaagaccatg
gactacctccattcccagggggttgttcatcgagacctgaagccgagtaacatcctgtac
agggatgagtcggggagcccagaatccatccgagtctgcgacttcggctttgccaagcag
ctgcgcgcggggaacgggctgctcatgacaccctgctacacggccaatttcgtggccccg
gaggtcctgaagcgtcaaggctatgatgcggcgtgtgacatctggagtttggggatcctg
ttgtacaccatgctggcaggatttaccccttttgcaaatgggccagacgatacccctgag
gagattctggcgcggatcggcagtgggaagtatgccctttctgggggaaactgggactcg
atatctgacgcagctaaagacgtcgtgtccaagatgctccacgtggaccctcatcagcgc
ctgacggcgatgcaagtgctcaaacacccgtgggtggtcaacagagagtacctgtcccca
aaccagctcagccgacaggacgtgcacctggtgaagggcgcgatggccgccacctacttt
gctctaaacagaacacctcaggccccgcggctggagcccgtgctgtcatccaacctggct
cagcgcagaggcatgaagagactcacgtccacgcggctgtag

  All links  
Disease (1)   
   OMIM (1)   
Gene (9)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (67)   
   RefSeq(nuc) (13)   
   GenBank (27)   
   EMBL (27)   
Protein domain (11)   
   Pfam (11)   
All databases (103)   

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