KEGG   Homo sapiens (human): 8565
Entry
8565              CDS       T01001                                 
Symbol
YARS1, CMTDIC, IMNEPD2, TYRRS, YARS, YRS, YTS
Name
(RefSeq) tyrosyl-tRNA synthetase 1
  KO
K01866  tyrosyl-tRNA synthetase [EC:6.1.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00264  Charcot-Marie-Tooth disease
H02391  Infantile-onset multisystem neurologic, endocrine, and pancreatic disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    8565 (YARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    8565 (YARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    8565 (YARS1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    8565 (YARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.1  tyrosine---tRNA ligase
     8565 (YARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (A)
   8565 (YARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    8565 (YARS1)
 Prokaryotic type
    8565 (YARS1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    8565 (YARS1)
SSDB
Motif
Pfam: tRNA-synt_1b tRNA_bind
Other DBs
NCBI-GeneID: 8565
NCBI-ProteinID: NP_003671
OMIM: 603623
HGNC: 12840
Ensembl: ENSG00000134684
UniProt: P54577 A0A0S2Z4R1
Structure
Position
1:complement(32775239..32817358)
AA seq 528 aa
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
NT seq 1587 nt   +upstreamnt  +downstreamnt
atgggggacgctcccagccctgaagagaaactgcaccttatcacccggaacctgcaggag
gttctgggggaagagaagctgaaggagatactgaaggagcgggaacttaaaatttactgg
ggaacggcaaccacgggcaaaccacatgtggcttactttgtgcccatgtcaaagattgca
gacttcttaaaggcagggtgtgaggtaacaattctgtttgcggacctccacgcatacctg
gataacatgaaagccccatgggaacttctagaactccgagtcagttactatgagaatgtg
atcaaagcaatgctggagagcattggtgtgcccttggagaagctcaagttcatcaaaggc
actgattaccagctcagcaaagagtacacactagatgtgtacagactctcctccgtggtc
acacagcacgattccaagaaggctggagctgaggtggtaaagcaggtggagcaccctttg
ctgagtggcctcttataccccggactgcaggctttggatgaagagtatttaaaagtagat
gcccaatttggaggcattgatcagagaaagattttcacctttgcagagaagtacctccct
gcacttggctattcaaaacgggtccatctgatgaatcctatggttccaggattaacaggc
agcaaaatgagctcttcagaagaggagtccaagattgatctccttgatcggaaggaggat
gtgaagaaaaaactgaagaaggccttctgtgagccaggaaatgtggagaacaatggggtt
ctgtccttcatcaagcatgtcctttttccccttaagtccgagtttgtgatcctacgagat
gagaaatggggtggaaacaaaacctacacagcttacgtggacctggaaaaggactttgct
gctgaggttgtacatcctggagacctgaagaattctgttgaagtcgcactgaacaagttg
ctggatccaatccgggaaaagtttaatacccctgccctgaaaaaactggccagcgctgcc
tacccagatccctcaaagcagaagccaatggccaaaggccctgccaagaattcagaacca
gaggaggtcatcccatcccggctggatatccgtgtggggaaaatcatcactgtggagaag
cacccagatgcagacagcctgtatgtagagaagattgacgtgggggaagctgaaccacgg
actgtggtgagcggcctggtacagttcgtgcccaaggaggaactgcaggacaggctggta
gtggtgctgtgcaacctgaaaccccagaagatgagaggagtcgagtcccaaggcatgctt
ctgtgtgcttctatagaagggataaaccgccaggttgaacctctggaccctccggcaggc
tctgctcctggtgagcacgtgtttgtgaagggctatgaaaagggccaaccagatgaggag
ctcaagcccaagaagaaagtcttcgagaagttgcaggctgacttcaaaatttctgaggag
tgcatcgcacagtggaagcaaaccaacttcatgaccaagctgggctccatttcctgtaaa
tcgctgaaaggggggaacattagctag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (31)   
   RefSeq(nuc) (3)   
   GenBank (14)   
   EMBL (14)   
3D Structure (8)   
   PDB (8)   
Protein domain (2)   
   Pfam (2)   
All databases (86)   

Download RDF
DBGET integrated database retrieval system