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3EMG:
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
PDB ID:
3EMG
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MMDB ID:
68294
PDB Deposition Date:
2008/9/24
Updated in MMDB:
2008/12
Experimental Method:
x-ray diffraction
Resolution:
2.6 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 3EMG: monomeric; determined by author and by software (PISA)
Molecular Components in 3EMG
Label
Count
Molecule
Protein (1 molecule)
A
1
Tyrosine-protein Kinase SYK
(Gene symbol:
SYK
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303