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3NZS:
Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase
PDB ID:
3NZS
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MMDB ID:
87615
PDB Deposition Date:
2010/7/16
Updated in MMDB:
2010/12
Experimental Method:
x-ray diffraction
Resolution:
2.75 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 3NZS: monomeric; determined by author and by software (PISA)
Molecular Components in 3NZS
Label
Count
Molecule
Protein (1 molecule)
A
1
Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol:
PIK3CG
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
6-(1,1-dioxidothiomorpholin-4-yl)-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303