1O5M: Structure of FPT bound to the inhibitor SCH66336

PDB ID: 1O5MDownload
MMDB ID: 24981
PDB Deposition Date: 2003/9/26
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 1O5M: dimeric; determined by author and by software (PISA)
Molecular Components in 1O5M
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Alpha Subunit
(Gene symbol: Fnta)
Molecule annotation
1
Protein Farnesyltransferase Beta Subunit
(Gene symbol: Fntb)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
ZINC IONZINC ION
2
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
3
1
4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303