3CCZ: Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors

PDB ID: 3CCZDownload
MMDB ID: 64992
PDB Deposition Date: 2008/2/26
Updated in MMDB: 2017/11
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 3CCZ: tetrameric; determined by author and by software (PISA)
Molecular Components in 3CCZ
Label Count Molecule
Proteins (4 molecules)
4
3-hydroxy-3-methylglutaryl-coenzyme a Reductase
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
SULFATE IONSULFATE ION
2
4
(3R,5R)-7-[2-(4-fluorophenyl)-4-{[(1S)-2-hydroxy-1-phenylethyl]carbamoyl}-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid(3R,5R)-7-[2-(4-fluorophenyl)-4-{[(1S)-2-hydroxy-1-phenylethyl]carbamoyl}-5-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyheptanoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303